The Company presented data at the TCT meeting in February 2019 on the development candidate, an anti-CD117
amanitin ADC, showing that it potently and selectively depleted hematopoietic stem cells in non-human primates while preserving the immune system.
An anti-CD117 ADC conjugated with
amanitin potently depleted human and non-human primate hematopoietic stem cells and progenitors in vivo.
Antibody Targeted
Amanitin Conjugates (ATACs), to improve efficiencies of ADCs.
Amatoxins, consisting of alpha, beta, and gamma
amanitin, account for >90% of deaths related to mushroom poisoning worldwide (1).
Amanita phalloides contains
amanitin, inhibiting RNA polymerase II.
Amanitin poisoning is distinguished bythree clinical stages: an incubation stage, a gastrointestinal stage and a cytotoxic stage.
Its killer poison,
amanitin, damages the liver and kidneys.
arms and
amanitin, radioactive sustenance, high explosive, currency and mint, security printing and alcohol beverages.